LEPICORTINOLO

Lepicortinolo has Prednisolone as its active substance.

Prednisolone is a glucocorticoid derived from hydrocortisone, with anti-inflammatory and immunosuppressive properties that are used in the treatment of numerous disease states which is reported on this site as well https://pillintrip.com/medicine/lepicortinolo.

Pharmacotherapeutic group:8.2.2 Glucocorticoids
ATC code:H02AB06 Prednisolone

Therapeutic indications

Lepicortinolo is indicated in the short-term treatment and/or in systemic exacerbations and complications refractory to other therapeutic measures of

A) Rheumatic and collagen diseases ? Rheumatoid arthritis, rheumatic carditis, Wegner’s granulomatosis, dermatomyositis and polymyositis, Polyarteritis Nodosa (PAN), temporal arthritis and/or polymyalgia rheumatica.

B) Respiratory diseases ? acute episodes of asthma, sarcoidosis, advanced pulmonary tuberculosis (in conjunction with appropriate anti-tuberculous medication), Pneumocystis carinii pneumonia in AIDS patients, interstitial pulmonary fibrosis.

C) Allergies ? angioedema, hypersensitivity to drugs and serum sickness.

D) Hematological diseases ? autoimmune idiopathic thrombocytopenic purpura (ITP), autoimmune hemolytic anemia, erythroblastopenias.

E) Neoplastic diseases ? when administered by an experienced oncologist, in the palliative treatment of leukemias and lymphomas, multiple myeloma and as antihemetic in the course of immunosuppressive therapy.

F) Dermatological diseases ? pemphigus, dermatitis herpetiformis, erythema multiforme gravis (Stevens-Johnson Syndrome), uncontrolled eczema, sarcoidosis cutis, mycosis fungoides, lichen planus and toxidermias.

G) Renal diseases ? nephrotic syndrome.

H) Liver and gastrointestinal diseases ? Aggravation of Crohn’s disease and ulcerative colitis, chronic autoimmune hepatitis, celiac disease.

I) Neurological disorders ? myasthenia, cerebral edema (in particular of traumatic or tumoral cause), cerebral palsy, multiple sclerosis, radiculopathies.

J) Ophthalmological diseases ? severe anterior and posterior uveitis.

What should be taken into consideration before using it?
Do not take Lepicortinolo

-if you are allergic (hypersensitive) to Prednisolone or any of the other ingredients of Lepicortinolo.
-if you have a bacterial or fungal infection that is not controlled by specific treatment. -if you are suffering from uncontrolled psychotic conditions.
-if you have recently undergone vaccination with live attenuated agents.

Take special care with Lepicortinolo

If you have an infection (virus, bacteria or fungus) you need close medical supervision. Lepicortinolo, like all glucocorticoids, can mask signs of infection and increase your risk of infection. Prolonged treatment increases the possibility of infection of the eyes, by viruses or fungi.
If you have latent tuberculosis or a positive reaction to tuberculin, you need periodic medical examinations, given the risk of reactivation of tuberculosis; your doctor will decide whether to prescribe preventive treatment.
When Lepicortinolo is discontinued after prolonged treatment, muscle and joint pain, fever and malaise may appear.
Caution should be exercised in the following situations:

Heart disease, thromboembolism, and hypertension. You may need to decrease salt in food and eat fruits rich in potassium (bananas, oranges).
Gastritis or esophagitis, diverticulitis, ulcerative colitis (if there is imminent risk of perforation, abscess, or infection with pus), recent surgical operation with suture of the intestinal wall, ulcer of the stomach or duodenum.
Diabetes, osteoporosis, myasthenia gravis, renal failure
Emotional instability.
Psychotic tendencies
Epilepsy
Hypothyroidism or liver cirrhosis may increase the effects of the drug.
Herpes simplex ocularis (risk of corneal perforation).
Prolonged treatment in children (delayed growth and development).
During prolonged treatment with Lepicortinolo, or within 12 months after discontinuation of prolonged treatment, you may need to increase the dose, resume medication, or receive an intravenous corticosteroid appropriate to the situation. Consult your doctor; it is important to let him or her know that you are or have been taking Lepicortinolo for months.

Taking Lepicortinolo with other medicines

Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Phenobarbital, phenytoin, rifampin, coumarin anticoagulants and ephedrine decrease the effect of Lepicortinolo, making it necessary to increase the maintenance dose. On the other hand, erythromycin, estrogens and oral contraceptives increase the effect of Lepicortinolo, which may require a reduction in the maintenance dose.
There is also the possibility of interaction of prednisolone with quinolones (such as ofloxacin, norfloxacin and ciprofloxacin, among others).

Pregnancy and lactation

Consult your doctor or pharmacist before taking any medication.

Lepicortinolo is not recommended during pregnancy and lactation but it is up to the doctor to evaluate the benefit/risk ratio and decide the best therapeutic course of action.

Driving and using machines

The effects on the ability to drive and use machines have not been studied.

Important information about some of the ingredients of Lepicortinolo

Lepicortinolo tablets contain lactose and should be used with caution in patients with malabsorption syndromes, intolerance or altered carbohydrate metabolism.

How is it used?
Always take Lepicortinolo as directed by your doctor. Talk to your doctor or pharmacist if you have questions.

Dosage varies according to the severity of the condition, age, patient’s weight, and therapeutic response.
The average daily dose varies widely, from 10 to 100 mg in adults and around 1 mg/kg in children.
No maximum dose is known.
According to the response to the drug and the clinical situation, the doctor will try to gradually reduce the initial dose until the minimum effective dose is reached. If it is possible, the doctor will decide to stop the treatment gradually.

Mode and route of administration
Oral: tablets.
Intramuscular or intravenous use: powder and solvent for solution for injection. Before injection, the lyophilized is dissolved with the solvent (ampoule with liquid that comes with the ampoule with the powder) and the solution is aspirated into the syringe.

The intramuscular and intravenous form is generally reserved for patients unable to swallow tablets or emergent situations.

If you take more Lepicortinolo than you should
Intoxication is not expected, but if it were to occur, it would be recommended that measures be implemented according to the symptoms presented.

If you forgot to take Lepicortinolo
It is important to take all the doses prescribed by your doctor. When one or more doses are missed, treatment should continue with the dose indicated by the doctor.Do not take a double dose to make up for a missed dose.

If you stop taking Lepicortinolo

Lepicortinolo should be stopped gradually, on your doctor’s advice and under his supervision.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

What are possible side effects?
Like other medicines, Lepicortinolo can cause side effects in some people.

Lepicortinolo is a glucocorticoid and therefore may cause several undesirable effects, especially when treatment needs to be prolonged: increased susceptibility to infections, digestive changes, hydro-electrolyte imbalance, muscle and bone effects, skin effects, neuropsychiatric changes, ophthalmic effects, endocrine effects, and rare cases of allergic reactions.

If any of the side effects gets worse or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

How should it be stored?
Keep out of the reach and sight of children.
Store in the original package. Do not store above 25°C.
Do not use Lepicortinolo after the expiration date which is stated on the carton.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines you no longer need. These measures will help to protect the environment.

More information about Lepicortin
What Lepicortinolo contains

The active substance is Prednisolone.
The other ingredients are :
Tablets:cornstarch, microcrystalline cellulose, lactose and magnesium stearate.
Powder and solvent for solution for injection (IM/IV):
Lepicortinolo 25 mg/ 1 ml
Powder for solution for injection: disodium phosphate dihydrate, monosodium phosphate monohydrate, sodium carbonate, benzalkonium chloride.
Solvent: water for injections.
Lepicortinolo 250 mg/ 2ml
Powder for solution for injection: sodium hydroxide, benzalkonium chloride. Solvent: water for injections.

What Lepicortinolo looks like and contents of the pack
Tablets: PVC and aluminum blister. Each blister contains 10 tablets. Packs of 20 and 60 tablets.
Powder and solvent for solution for injection at 25 mg / 1 ml: packaged in 1 ml ampoules of clear glass.
Packages of 1 and 3 units.
Powder and solvent for solution for injection at 250 mg/2 ml: packed in 2 ml ampoules of clear glass.
Packages of 1 unit.