How to choose a drug for headache relief? The problem of choosing a symptomatic drug for migraine remains very acute. Many years of clinical practice show that despite a wide arsenal of symptomatic drugs for migraine treatment, in general the relief of an attack remains an unresolved problem, and many patients are not satisfied with the drugs taken. The combined medication Polygot can help to cope with the symptoms of migraine. The effect of Polygot is associated with the vasoconstrictor effect of ergotamine and improvement of brain functions under the influence of caffeine. Ergotamine has a vasoconstrictor effect. The difficulty in controlling an attack may be due to a number of reasons, but the most likely are lack of proper professional supervision, self-medication practices and selection of suboptimal medication, use of nonspecific agents, and delayed medication administration during a migraine attack. There are many unresolved questions regarding the evaluation of the efficacy of these agents, doses, duration of effects, timing of use, the possibility of using a single agent and combining different classes, and the effect on other related symptoms, which may also significantly affect patients’ functional activity during a migraine attack. According to experts, one of the most adequate ways to assess efficacy, safety, duration and persistence of effect (in different attacks and within a single attack) is an analysis of subjective preferences and patient satisfaction.
Polygot is used for the treatment of headache of vascular genesis (including migraine). It is a combination drug. Ergotamine is a natural ergot alkaloid, increases the tone of dilated extracranial arteries, affects serotonin receptors. Caffeine accelerates and increases absorption of ergotamine. After oral administration, about 62% of ergotamine is absorbed in the gastrointestinal tract. Maximum plasma concentrations are reached 2 hours after oral administration. Binding to plasma proteins is 98%. Ergotamine is metabolized in the liver to form pharmacologically active metabolites. Ergotamine is excreted mainly with bile both unchanged and as metabolites. Excretion is biphasic, with half-lives of 2.7 hours and 21 hours for I and II phases, respectively. After oral administration caffeine is absorbed quickly and almost completely. Binding with plasma proteins is 35%. Caffeine is almost completely metabolized in the body. Metabolites are excreted mainly with urine. The elimination half-life is about 3.5 hours.
The drug polygot is taken orally. Two tablets are taken at the beginning of an attack; if necessary, one tablet at 30-minute intervals until the condition improves, not exceeding the maximum daily dose (6 tablets). The maximum weekly dose is 10 tablets. In subsequent attacks, the initial dose is increased to 3 tablets, depending on the total dose taken during the previous attacks.
The prescription medication information on this website is for professionals only. The information contained on this site should not be used by patients to make an independent decision on the use of the medications presented and should not serve as a substitute for a face-to-face consultation with a physician.